Synergistic effect of ethanol extracts of Vernonia amygdalina and Croton zambesicus in alloxan-induced diabetic rats

Introduction: Therapeutic application of medicinal plants is largely based on their chemical contents which synergistically work together in the same or different plants. Aims: This research assessed synergistic antidiabetic and hypolipidemic potential ethanol leaf extract Vernonia amygdalina (VAMG) Croton zambesicus (CZMG) alloxan-induced diabetic male Wistar rats other to justify traditional extracts as agents. Materials Methods: The were collected, air-dried, extracted separately produce respective (VAMG CZMG). Secondary metabolites each screened using standard methods. acute toxicity tests carried out determine median lethal dose (LD50) extracts. animals induced with diabetics alloxan monohydrate ones showing fasting blood glucose 250 mg/ dL used for study. sugar levels body weights observed after administration combined 28 days. effects lipid profile hepatic enzymes also studied. Results: contained tannins, flavonoids, saponins, phenolics glycosides. Moreover, exposure plant (VACZ) caused a significantly (P < .05) reduced concentration, serum ALT, ALP, AST, total cholesterol, triglycerides, LDL VLDL an increased weight, protein HDL cholesterol. activity was comparable glibenclamide. Conclusion: Thus, tested bioactive components whose could trigger significant reduction concentration regulates indices than during single administration. extracts’ biological glibenclamide, be development candidate. results confirmed scientific basis these